CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

doi:10.1111/j.1369-1600.2011.00349.x

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Article

CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Addiction biology - 1 Jul 2013

Levran Orna, Peles Einat, Hamon Sara, Randesi Matthew, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

Adequate methadone dosing in methadone maintenance treatment (MMT) for opioid addiction is critical for therapeutic success. One of the challenges in dose determination is the inter-individual variability in dose-response. Methadone metabolism is attributed primarily to cytochrome P450 enzymes CYP3A4, CYP2B6 and CYP2D6. The CYP2B6*6 allele [single nucleotide polymorphisms (SNPs) 785A>G (rs2279343) and 516G>T...

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Identifiers

PMID: 21790905
DOI: 10.1111/j.1369-1600.2011.00349.x
PMCID: PMC3735354

Genes

ABCB1

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