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Article

Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy.

Pharmacogenetics and genomics - 1 Jan 2022

Chen Yen-Jung, Lu Ju-Ting, Huang Chun-Wei, Wu Wei-Hsin, Lee Kuei-Fang, Liu Hsin-Tzu, Shih-Hsin Wu Lawrence

Abstract excerpt

OBJECTIVES: Opioid dependence is currently one of the most serious problems affecting the social norms and public health system. Methadone maintenance therapy (MMT) is being widely used in treating heroin-dependent patients. The mechanism of methadone metabolism and disposition has been shown to involve cytochrome P450 (CYP450) and P-glycoprotein. The aim of this study was to explore the relationships among...

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Source

Identifiers

PMID: 34380995
DOI: 10.1097/FPC.0000000000000450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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