Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity.

British journal of clinical pharmacology - 1 Jun 2015

Mouly Stéphane, Bloch Vanessa, Peoc'h Katell, Houze Pascal, Labat Laurence, Ksouda Kamilia, Simoneau Guy, Declèves Xavier, Bergmann Jean Francois, Scherrmann Jean-Michel, Laplanche Jean-Louis, Lepine Jean-Pierre, Vorspan Florence

Abstract excerpt

AIMS: Methadone is characterized by wide intersubject variability regarding the dose needed to obtain full therapeutic response. We assessed the influence of sociodemographic, ethnic, clinical, metabolic and genotypic variables on methadone maintenance dose requirement in opioid-dependent responder patients. METHODS: Eighty-one stable patients (60 men and 21 women, 43.7 ± 8.1 years old, 63.1 ± 50.9 mg day(-1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Biotransformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A Inhibitors

Share to Drug Dosage Calculations

Share to Drug Monitoring

Share to Drug Users

Share to Heroin Dependence

Share to Methadone

Source

Open in PubMed Open full text

Identifiers

PMID: 25556837
DOI: 10.1111/bcp.12576
PMCID: PMC4456129

Genes

ABCB1
COMT
DRD2
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity.PMID 25556837Read ↗

Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.Semantic proximity Read ↗

OPRM1 and CYP3A4 association with methadone dose in Iranian patients undergoing methadone maintenance therapy.Semantic proximity Read ↗

CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.Semantic proximity Read ↗

ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.Semantic proximity Read ↗

Toward precision prescribing for methadone: Determinants of methadone deposition.Semantic proximity Read ↗

ABCB1, SLC22A1, COMT, and OPRM1 genotypes: Study of their influence on plasma methadone levels and clinical response to methadone maintenance treatment in opioid use disorder.Semantic proximity Read ↗

Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL studySemantic proximity Read ↗

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals.Semantic proximity Read ↗

ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.Semantic proximity Read ↗

CYP2B6 and ABCB1 genotypes predict methadone plasma exposure among patients on maintenance therapy against opioid addictions in Tanzania.Semantic proximity Read ↗

Pharmacogenomics of methadone maintenance treatment.Semantic proximity Read ↗

Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.