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Article

ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.

Human molecular genetics - 15 Jul 2008

Levran Orna, O'Hara Kimberly, Peles Einat, Li Dawei, Barral Sandra, Ray Brenda, Borg Lisa, Ott Jurg, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

Methadone is a mu-opioid receptor agonist used for treating opiate dependence. The range of effective methadone doses is broad. Part of the large inter-individual variability in efficacy may be accounted for by genetic factors. Methadone is a substrate of the transporter P-glycoprotein (P-gp) 170 that is encoded by the ABCB1 (MDR1) gene. Thus, P-gp variants may play a role in methadone absorption and...

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Source

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Identifiers

PMID: 18424454
DOI: 10.1093/hmg/ddn122
PMCID: PMC2599947

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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