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Article

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals.

Clinical pharmacology and therapeutics - 1 Dec 2006

Coller Janet K, Barratt Daniel T, Dahlen Karianne, Loennechen Morten H, Somogyi Andrew A

Abstract excerpt

BACKGROUND AND OBJECTIVES: The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable, and program retention rates are low due in part to nonoptimal dosing resulting in withdrawal symptoms and further heroin craving and use. Methadone is a substrate for the P-glycoprotein transporter, encoded by the...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17178268
DOI: 10.1016/j.clpt.2006.09.011

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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