OPRM1 and CYP3A4 association with methadone dose in Iranian patients undergoing methadone maintenance therapy.

doi:10.1080/10550887.2021.1886566

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Article

OPRM1 and CYP3A4 association with methadone dose in Iranian patients undergoing methadone maintenance therapy.

Journal of addictive diseases - 1 Jan 2000

Akbari Ahmad, Kheradmand Ali, Sina Marzie, Ahmadiani Abolhassan, Asadi Sareh

Abstract excerpt

BACKGROUND: Investigations proposed that genetic polymorphisms within proteins in methadone pharmacokinetic and pharmacodynamics are critical factors in determination of methadone dose in methadone maintenance therapy (MMT). OBJECTIVE: This study aimed to assess the associations between two polymorphisms, CYP3A4 (rs2740574) and OPRM1 (rs1799971), with dose of methadone in Iranian patients undergoing MMT. METHODS:...

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Identifiers

PMID: 33682628
DOI: 10.1080/10550887.2021.1886566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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