Article
Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome.
PloS one - 10 Feb 2011
Drini Musa, Wong Nicholas C, Scott Hamish S, Craig Jeffrey M, Dobrovic Alexander, Hewitt Chelsee A, Dow Christofer, Young Joanne P, Jenkins Mark A, Saffery Richard, Macrae Finlay A
Abstract excerpt
BACKGROUND: Hyperplastic Polyposis Syndrome (HPS) is a condition associated with multiple serrated polyps, and an increased risk of colorectal cancer (CRC). At least half of CRCs arising in HPS show a CpG island methylator phenotype (CIMP), potentially linked to aberrant DNA methyltransferase (DNMT) activity. CIMP is associated with methylation of tumor suppressor genes including regulators of DNA mismatch repair...
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