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Article

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer.

Oncogene - 18 Mar 2010

Worthley D L, Whitehall V L J, Buttenshaw R L, Irahara N, Greco S A, Ramsnes I, Mallitt K-A, Le Leu R K, Winter J, Hu Y, Ogino S, Young G P, Leggett B A

Abstract excerpt

There are two major molecular pathways to sporadic colorectal cancer, the chromosomal instability (CIN) and the CpG island methylator phenotype (CIMP) pathways. This study recruited 166 patients undergoing colonoscopy. Biopsy samples were collected from the cecum, transverse colon, sigmoid colon and rectum. DNA methylation was quantified at 'type A' (ESR1, GATA5, HIC1, HPP1, SFRP1) and 'type C' markers (MGMT,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19966864
DOI: 10.1038/onc.2009.449

Genes

ESR1
GATA5
HIC1
IGF2
MGMT
MLH1
NEUROG1
RUNX3
SFRP1
SOCS1

Provenance

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