Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.

doi:10.1016/j.brainres.2011.02.042

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Article

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.

Brain research - 18 Apr 2011

Taqi Malik Mumtaz, Bazov Igor, Watanabe Hiroyuki, Nyberg Fred, Yakovleva Tatjana, Bakalkin Georgy

Abstract excerpt

Single nucleotide polymorphism (rs1997794) in promoter of the prodynorphin gene (PDYN) associated with alcohol-dependence may impact PDYN transcription in human brain. To address this hypothesis we analyzed PDYN mRNA levels in the dorsolateral prefrontal cortex (dl-PFC) and hippocampus, both involved in cognitive control of addictive behavior and PDYN promoter SNP genotype in alcohol-dependent and control human...

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Identifiers

PMID: 21338584
DOI: 10.1016/j.brainres.2011.02.042

Genes

PDYN
FOSB
JUND

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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