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Article

Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.

Translational psychiatry - 20 Jun 2018

Bazov Igor, Sarkisyan Daniil, Kononenko Olga, Watanabe Hiroyuki, Karpyak Victor M, Yakovleva Tatiana, Bakalkin Georgy

Abstract excerpt

Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impairment of learning and memory, while KOR antagonists block excessive, compulsive-like drug and alcohol...

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Source

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Identifiers

PMID: 29925858
DOI: 10.1038/s41398-017-0075-5
PMCID: PMC6010434

Genes

PDYN
OPRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.PMID 29925858Read ↗

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