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Article

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.

Addiction biology - 1 Jul 2011

Taqi Malik Mumtaz, Bazov Igor, Watanabe Hiroyuki, Sheedy Donna, Harper Clive, Alkass Kanar, Druid Henrik, Wentzel Parri, Nyberg Fred, Yakovleva Tatjana, Bakalkin Georgy

Abstract excerpt

The genetic, epigenetic and environmental factors may influence the risk for neuropsychiatric disease through their effects on gene transcription. Mechanistically, these effects may be integrated through regulation of methylation of CpG dinucleotides overlapping with single-nucleotide polymorphis...

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Source

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Identifiers

PMID: 21521424
DOI: 10.1111/j.1369-1600.2011.00323.x
PMCID: PMC3391609

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21521424-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.PMID 21521424Read ↗

Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.Semantic proximity Read ↗

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.Semantic proximity Read ↗

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.Semantic proximity Read ↗

Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.Semantic proximity Read ↗

Prefrontal cortex eQTLs/mQTLs enriched in genetic variants associated with alcohol use disorder and other diseases.Semantic proximity Read ↗

An Exploratory Association Study of Alcohol Use Disorder and <scp>DNA</scp> MethylationSemantic proximity Read ↗

Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.Semantic proximity Read ↗

A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence.Semantic proximity Read ↗

Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene.Semantic proximity Read ↗

Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.Semantic proximity Read ↗

Multiple Functional Variants in cis Modulate PDYN Expression.Semantic proximity Read ↗

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence.Semantic proximity Read ↗

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