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Article

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence.

Neuroscience letters - 29 May 2006

Nomura Akira, Ujike Hiroshi, Tanaka Yuji, Otani Kyohei, Morita Yukitaka, Kishimoto Makiko, Morio Akiko, Harano Mutsuo, Inada Toshiya, Yamada Mitsuhiko, Komiyama Tokutaro, Sekine Yoshimoto, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

Abstract excerpt

Previous studies have indicated that genetic factors substantially affect development of substance use disorders, including methamphetamine dependence. Prodynorphin (PDYN) is an opioid peptide precursor that yields dynorphins, endogenous kappa opioid-receptor agonists that play important roles in substance abuse. A physiologically active polymorphism of 1-4 repeats of a 68-bp element in the promoter region of the...

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Source

Identifiers

PMID: 16529859
DOI: 10.1016/j.neulet.2006.02.038

Genes

PDYN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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