Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence.

Addiction biology - 1 Sept 2007

Williams Tanya J, LaForge K Steven, Gordon Derek, Bart Gavin, Kellogg Scott, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

There is strong evidence for a genetic contribution to individual differences in vulnerability to drug addictions. Studies have shown that the 68-base pair repeat polymorphism in the promoter region of the human prodynorphin gene contains a putative AP-1 binding site, and that three or four repeat copies result in greater transcriptional activation. Here, we report on a separate cohort of 302 subjects ascertained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Base Pairing
Share to Cocaine-Related Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Comorbidity

Share to Enkephalins

Share to Hispanic or Latino

Share to Protein Precursors

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 17559549
DOI: 10.1111/j.1369-1600.2007.00069.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence.PMID 17559549Read ↗

Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.Semantic proximity Read ↗

A functional prodynorphin promoter polymorphism and opioid dependence.Semantic proximity Read ↗

An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.Semantic proximity Read ↗

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.Semantic proximity Read ↗

Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence.Semantic proximity Read ↗

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.Semantic proximity Read ↗

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence.Semantic proximity Read ↗

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.Semantic proximity Read ↗

Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.Semantic proximity Read ↗

Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.Semantic proximity Read ↗

Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene.Semantic proximity Read ↗

Multiple Functional Variants in cis Modulate PDYN Expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.