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Article

Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Jun 2017

D'Addario Claudio, Shchetynsky Klementy, Pucci Mariangela, Cifani Carlo, Gunnar Agneta, Vukojević Vladana, Padyukov Leonid, Terenius Lars

Abstract excerpt

Dynorphins are critically involved in the development, maintenance and relapse of alcoholism. Alcohol-induced changes in the prodynorphin gene expression may be influenced by both gene polymorphisms and epigenetic modifications. The present study of human alcoholics aims to evaluate DNA methylation patterns in the prodynorphin gene (PDYN) promoter and to identify single nucleotide polymorphisms (SNPs) associated...

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Identifiers

PMID: 28336495
DOI: 10.1016/j.pnpbp.2017.03.012

Genes

PDYN

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Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.PMID 28336495Read ↗

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.Semantic proximity Read ↗

Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.Semantic proximity Read ↗

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.Semantic proximity Read ↗

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An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.Semantic proximity Read ↗

Multiple Functional Variants in cis Modulate PDYN Expression.Semantic proximity Read ↗

Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states.Semantic proximity Read ↗

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Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.Semantic proximity Read ↗

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence.Semantic proximity Read ↗

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.Semantic proximity Read ↗

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