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Article

Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.

American journal of medical genetics - 8 May 2002

Chen Andrew C H, LaForge K Steven, Ho Ann, McHugh Pauline F, Kellogg Scott, Bell Kathy, Schluger Rosemary P, Leal Suzanne M, Kreek Mary Jeanne

Abstract excerpt

It has been demonstrated that the opioid peptide dynorphin plays a role in modulating responses to several psychoactive substances including cocaine. Our laboratory and others have found that mRNA levels of dynorphin in the caudate and putamen are elevated after acute or chronic cocaine exposure...

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Share to Cocaine-Related Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

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Share to Repetitive Sequences, Nucleic Acid

Source

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Identifiers

PMID: 11992566
DOI: 10.1002/ajmg.10362
PMCID: PMC6148755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11992566-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.PMID 11992566Read ↗

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