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Article

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2009

Yuferov Vadim, Ji Fei, Nielsen David A, Levran Orna, Ho Ann, Morgello Susan, Shi Ruijin, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

Dynorphin peptides and the kappa-opioid receptor are important in the rewarding properties of cocaine, heroin, and alcohol. We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. We genotyped six single nucleotide polymorp...

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Source

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Identifiers

PMID: 18923396
DOI: 10.1038/npp.2008.187
PMCID: PMC2778041

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18923396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.PMID 18923396Read ↗

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