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Article

Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.

Oncogene - 23 Jun 2011

Serres M P, Zlotek-Zlotkiewicz E, Concha C, Gurian-West M, Daburon V, Roberts J M, Besson A

Abstract excerpt

p27(Kip1) (p27) can have opposing roles during malignant transformation depending on cellular context: on one hand it functions as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (CDK) activity in the nucleus and on the other it may adopt an oncogenic role that is less well understood. To gain further insight into the roles played by p27 during tumorigenesis, we compared the susceptibility with...

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Source

Identifiers

PMID: 21317921
DOI: 10.1038/onc.2011.9

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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