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Article

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.

Oncogene - 15 Oct 2009

Kelly-Spratt K S, Philipp-Staheli J, Gurley K E, Hoon-Kim K, Knoblaugh S, Kemp C J

Abstract excerpt

Reduced expression of the CDK inhibitor p27(Kip1) (p27) in human lung cancer correlates with tumor aggressiveness and poor prognosis. However, the regulation of p27 expression and the role of p27 during lung cancer are poorly understood. Urethane-induced lung tumors in mice frequently harbor mutations in the Kras oncogene, and in this study, we use this model to address the regulation of p27 during tumorigenesis....

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Identifiers

PMID: 19648963
DOI: 10.1038/onc.2009.226
PMCID: PMC2842079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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