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Article

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.

Oncogene - 15 Oct 2009

Kelly-Spratt K S, Philipp-Staheli J, Gurley K E, Hoon-Kim K, Knoblaugh S, Kemp C J

Abstract excerpt

Reduced expression of the CDK inhibitor p27(Kip1) (p27) in human lung cancer correlates with tumor aggressiveness and poor prognosis. However, the regulation of p27 expression and the role of p27 during lung cancer are poorly understood. Urethane-induced lung tumors in mice frequently harbor muta...

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Identifiers

PMID: 19648963
DOI: 10.1038/onc.2009.226
PMCID: PMC2842079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19648963-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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