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Article

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.

Cancer research - 1 Apr 2007

Pei Xin-Hai, Bai Feng, Smith Matthew D, Xiong Yue

Abstract excerpt

Mutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18(Ink4c) and p27(Kip1) develop a tumor spectrum reminiscent of human multiple endocrine neoplasia (MEN) syndromes. To determine how p18 and p27 genetically interact with Men1, the tumor suppressor gene mutated in familial MEN1, we characterized p18-Men1 and p27-Men1 double mutant mice and showed that p18, but not p27, functionally collaborates...

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Topics

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Share to Carcinoma, Non-Small-Cell Lung
Share to Cyclin-Dependent Kinase Inhibitor p18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Source

Identifiers

PMID: 17409423
DOI: 10.1158/0008-5472.CAN-06-4517

Genes

CDK2
CDK4
CDK6
MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.PMID 17409423Read ↗

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