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Article

Identification of oncogenes collaborating with p27 <sup>Kip1</sup> loss by insertional mutagenesis and high-throughput insertion site analysis

31 Jul 2002

Abstract excerpt

The p27(Kip1) protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human cancers, and p27 functions as a tumor suppressor that exhibits haploinsufficiency in mice. Despite the well characterized role of p27 as a cyclin-dependent kinase inhibitor, its mechanism of tumor suppression is unknown. We used Moloney murine leukemia...

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PMID: 12151601
DOI: 10.1073/pnas.162356099

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Source receipt: pubmed, retrieved 7 Sept 2026.

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