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p57Kip2 and Cancer: Time for a Critical Appraisal

5 Aug 2011

Abstract excerpt

p57(Kip2) is a cyclin-dependent kinase inhibitor belonging to the Cip/Kip family, which also includes p21(Cip1) and p27(Kip1). So far, p57(Kip2) is the least-studied Cip/Kip protein, and for a long time its relevance has been related mainly to its unique role in embryogenesis. Moreover, genetic and molecular studies on animal models and patients with Beckwith-Wiedemann syndrome have shown that alterations in...

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PMID: 21816904
DOI: 10.1158/1541-7786.mcr-11-0220

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