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Article

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.

Genes & development - 15 Jul 2007

Besson Arnaud, Hwang Harry C, Cicero Samantha, Donovan Stacy L, Gurian-West Mark, Johnson Dianna, Clurman Bruce E, Dyer Michael A, Roberts James M

Abstract excerpt

The cell cycle inhibitor p27Kip1 also has cyclin-cyclin-dependent kinase (CDK)-independent functions. To investigate the significance of these functions in vivo, we generated a knock-in mouse in which four amino acid substitutions in the cdkn1b gene product prevent its interaction with cyclins and CDKs (p27CK-). In striking contrast to complete deletion of the cdkn1b gene, which causes spontaneous tumorigenesis...

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Identifiers

PMID: 17626791
DOI: 10.1101/gad.1556607
PMCID: PMC1920168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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