Article
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.
Molecular and cellular biology - 1 Sept 2009
Berton Stefania, Belletti Barbara, Wolf Katarina, Canzonieri Vincenzo, Lovat Francesca, Vecchione Andrea, Colombatti Alfonso, Friedl Peter, Baldassarre Gustavo
Abstract excerpt
In many human cancers, p27 downregulation correlates with a worse prognosis, suggesting that p27 levels could represent an important determinant in cell transformation and cancer development. Using a mouse model system based on v-src-induced transformation, we show here that p27 absence is always linked to a more aggressive phenotype. When cultured in three-dimensional contexts, v-src-transformed p27-null...
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