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Article

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2009

Susaki Etsuo, Nakayama Keiko, Yamasaki Lili, Nakayama Keiichi I

Abstract excerpt

Although p27 and p57 are structurally related cyclin-dependent kinase inhibitors (CKIs), and are thought to perform similar functions, p27 knockout (p27(KO)) and p57(KO) mice show distinct phenotypes. To elucidate the in vivo functions of these CKIs, we have now generated a knock-in mouse model (p57(p27KI)), in which the p57 gene has been replaced with the p27 gene. The p57(p27KI) mice are viable and appear...

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Identifiers

PMID: 19276117
DOI: 10.1073/pnas.0811712106
PMCID: PMC2664003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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