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Article

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.

RNA (New York, N.Y.) - 1 Feb 1996

He F, Brown A H, Jacobson A

Abstract excerpt

Rapid turnover of nonsense-containing mRNAs in the yeast Saccharomyces cerevisiae is dependent on the products of the UPF1 (Upf1p), NMD2/UPF2 (Nmd2p) and UPF3 (Upf3p) genes. Mutations in each of these genes lead to the selective stabilization of mRNAs containing early nonsense mutations without affecting the decay rates of most other mRNAs. NMD2 was recently identified in a two-hybrid screen as a gene that...

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Identifiers

PMID: 8601282
PMCID: PMC1369360

Genes

UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.PMID 8601282Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Semantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6.Semantic proximity Read ↗

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts.Semantic proximity Read ↗

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.Semantic proximity Read ↗

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.Semantic proximity Read ↗

Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3BSemantic proximity Read ↗

Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicaseSemantic proximity Read ↗

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