Article
Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.
RNA (New York, N.Y.) - 1 Feb 1996
He F, Brown A H, Jacobson A
Abstract excerpt
Rapid turnover of nonsense-containing mRNAs in the yeast Saccharomyces cerevisiae is dependent on the products of the UPF1 (Upf1p), NMD2/UPF2 (Nmd2p) and UPF3 (Upf3p) genes. Mutations in each of these genes lead to the selective stabilization of mRNAs containing early nonsense mutations without a...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Base Sequence
- Fungal Proteins
- Molecular Sequence Data
- Mutation
- RNA Helicases
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- Saccharomyces cerevisiae