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Article

Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants.

Nucleic acids research - 1 Jun 2011

Iben James R, Epstein Jonathan A, Bayfield Mark A, Bruinsma Monique W, Hasson Samuel, Bacikova Dagmar, Ahmad Daniel, Rockwell Denise, Kittler Ellen L W, Zapp Maria L, Maraia Richard J

Abstract excerpt

We used a genetic screen based on tRNA-mediated suppression (TMS) in a Schizosaccharomyces pombe La protein (Sla1p) mutant. Suppressor pre-tRNA(Ser)UCA-C47:6U with a debilitating substitution in its variable arm fails to produce tRNA in a sla1-rrm mutant deficient for RNA chaperone-like activity. The parent strain and spontaneous mutant were analyzed using Solexa sequencing. One synonymous single-nucleotide...

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Identifiers

PMID: 21317186
DOI: 10.1093/nar/gkr066
PMCID: PMC3113579

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Source receipt: pubmed, retrieved 7 Sept 2026.

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