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Article

Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms.

The Journal of biological chemistry - 24 Apr 2009

Hellmann Rachel A, Martinis Susan A

Abstract excerpt

Quality control mechanisms during protein synthesis are essential to fidelity and cell survival. Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine amino acids including isoleucine, methionine, and norvaline. To prevent translational errors, mischarged tRNA products are translocated 30A from the canonical aminoacylation core to a hydrolytic editing-active site within a completely separate domain. Because it...

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Identifiers

PMID: 19258309
DOI: 10.1074/jbc.M807395200
PMCID: PMC2670153

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Source receipt: pubmed, retrieved 7 Sept 2026.

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