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Article

An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.

Genetics - 26 May 2023

Hurtig Jennifer E, van Hoof Ambro

Abstract excerpt

tRNA splicing endonuclease (TSEN) has a well-characterized role in transfer RNA (tRNA) splicing but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and an unknown essential function. In this study, we use yeast genetics to characterize the unknown tRNA-independent function(s) of TSEN. Using a high-copy suppressor screen, we...

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Identifiers

PMID: 36943791
DOI: 10.1093/genetics/iyad044
PMCID: PMC10213494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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