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Article

Alpha-synuclein and heroin craving in opiate-dependent patients on injectable heroin maintenance.

Addiction biology - 1 Sept 2012

Dürsteler-MacFarland Kenneth M, Brugger Isabelle, Bönsch Dominikus, Schmid Otto, Kornhuber Johannes, Bleich Stefan, Wiesbeck Gerhard A

Abstract excerpt

Research suggests that alpha-synuclein (SNCA) and NACP-Rep1, a polymorphic complex microsatellite repeat ~10 kb upstream of the SNCA gene translational start, may be involved in substance-use behaviors and craving. This study was the first to examine the effects of diacetylmorphine (DAM) on peripheral SNCA protein expression along with craving in opiate-dependent patients and to compare their NACP-Rep1 allele...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heroin Dependence

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Share to Polymorphism, Genetic

Share to Repetitive Sequences, Nucleic Acid

Share to Substance Abuse, Intravenous

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Source

Identifiers

PMID: 21309955
DOI: 10.1111/j.1369-1600.2010.00293.x

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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