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Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons

28 May 2019

Abstract excerpt

Methamphetamine (Meth) produces a variety of epigenetic effects in the brain, which are seminal to establish long-lasting alterations in neuronal activity. However, most epigenetic changes were described by measuring the rough amount of either histone acetylation and methylation or direct DNA methylation, without focusing on a specific DNA sequence. This point is key to comprehend Meth-induced phenotypic changes,...

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PMID: 31150652
DOI: 10.1016/j.brainres.2019.05.035

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