Article
Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations.
Alcoholism, clinical and experimental research - 1 Apr 2007
Clarimon Jordi, Gray Rebecca R, Williams Lindsey N, Enoch Mary-Anne, Robin Robert W, Albaugh Bernard, Singleton Andrew, Goldman David, Mulligan Connie J
Abstract excerpt
BACKGROUND: Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease. Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders. METHODS: Fifteen single-nucleotide polymorphisms (SNPs) in the...
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