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Article

Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence.

Human molecular genetics - 1 Apr 2005

Bönsch D, Lederer T, Reulbach U, Hothorn T, Kornhuber J, Bleich S

Abstract excerpt

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. Recently, it has been shown that alpha synuclein mRNA is increased in alcohol-dependent patients within withdrawal state. This increase is significantly associated with craving, especially obsessive craving. On the basis of these observations, the...

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Identifiers

PMID: 15731118
DOI: 10.1093/hmg/ddi090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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