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Article

Reduced expression of α-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype.

Addiction biology - 1 May 2014

Janeczek Paulina, MacKay Rachel K, Lea Rodney A, Dodd Peter R, Lewohl Joanne M

Abstract excerpt

α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify α-synuclein mRNA expression in autopsy samples of human dorsolateral prefrontal cortex. Because...

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Identifiers

PMID: 22974310
DOI: 10.1111/j.1369-1600.2012.00495.x
PMCID: PMC3543514

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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