Article
Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.
Biological psychiatry - 1 Jun 2007
Kalayasiri Rasmon, Sughondhabirom Atapol, Gueorguieva Ralitza, Coric Vladimir, Lynch Wendy J, Lappalainen Jaakko, Gelernter Joel, Cubells Joseph F, Malison Robert T
Abstract excerpt
BACKGROUND: Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively. METHODS: Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic...
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