Article
A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2020
Ruan Qiu T, Yazdani Neema, Blum Benjamin C, Beierle Jacob A, Lin Weiwei, Coelho Michal A, Fultz Elissa K, Healy Aidan F, Shahin John R, Kandola Amarpreet K, Luttik Kimberly P, Zheng Karen, Smith Nathaniel J, Cheung Justin, Mortazavi Farzad, Apicco Daniel J, Ragu Varman Durairaj, Ramamoorthy Sammanda, Ash Peter E A, Rosene Douglas L, Emili Andrew, Wolozin Benjamin, Szumlinski Karen K, Bryant Camron D
Abstract excerpt
Individual variation in the addiction liability of amphetamines has a heritable genetic component. We previously identified Hnrnph1 (heterogeneous nuclear ribonucleoprotein H1) as a quantitative trait gene underlying decreased methamphetamine-induced locomotor activity in mice. Here, we showed that mice (both females and males) with a heterozygous mutation in the first coding exon of Hnrnph1 (H1+/-) showed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.