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Article

Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype.

Journal of the American College of Cardiology - 15 Jan 2013

Almontashiri Naif A M, Fan Meng, Cheng Brian L M, Chen Hsiao-Huei, Roberts Robert, Stewart Alexandre F R

Abstract excerpt

OBJECTIVES: Because post-transcriptional mechanisms modulate levels of p16 (encoded by CDKN2A) and p15 (encoded by CDKN2B), we tested whether interferon-γ regulates the expression of these proteins and the effect of the 9p21 genotype. BACKGROUND: The mechanism whereby the common variant at chromosome 9p21.3 confers risk for coronary artery disease (CAD) remains uncertain. A recent report proposed that 9p21.3...

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Identifiers

PMID: 23199516
DOI: 10.1016/j.jacc.2012.08.1020

Genes

CAD

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