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Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth

17 Feb 2011

Abstract excerpt

TIA (T-cell intracellular antigen) proteins function as DNA/RNA trans-acting regulators to expand transcriptome and proteome diversity in mammals. In the present paper we report that the stable silencing of TIA1 and/or TIAR/TIAL1 (TIA1-related/like protein 1) expression in HeLa cells enhances cell proliferation, anchorage-dependent and -independent growth and invasion. HeLa cells lacking TIA1 and/or TIAR generate...

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PMID: 21284605
DOI: 10.1042/bj20101030

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