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Claudin-4 modulates autophagy via SLC1A5/LAT1 as a tolerance mechanism for genomic instability in ovarian cancer

2024-01-20

Abstract excerpt

Genome instability is key for tumor heterogeneity and derives from defects in cell division and DNA damage repair. Tumors show tolerance for this characteristic, but its accumulation is regulated somehow to avoid catastrophic chromosomal alterations and cell death. Claudin-4 is upregulated and closely associated with genome instability and worse patient outcome in ovarian cancer. This protein is commonly described...

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Literature Corpus work
e507e9ad-cb61-5883-9b4f-063b4dd073d9
DOI
10.1101/2024.01.18.576263
Open publication

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Claudin-4 modulates autophagy via SLC1A5/LAT1 as a tolerance mechanism for genomic instability in ovarian cancerDOI 10.1101/2024.01.18.576263
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