Article
Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells.
Clinical & experimental metastasis - 1 Jan 2006
Minard Meghan E, Ellis Lee M, Gallick Gary E
Abstract excerpt
The guanine nucleotide exchange factor Tiam1 regulates numerous biologic properties including migration and invasion. We demonstrated previously that colon tumor cells biologically selected for increased migration were increased in Tiam1 expression. Cells selected for increased Tiam1 expression or that ectopically overexpress Tiam1 were increased in metastatic potential. Here, we demonstrate that Tiam1 regulates...
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