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Article

TIA-1 or TIAR is required for DT40 cell viability.

The Journal of biological chemistry - 21 Mar 2003

Le Guiner Caroline, Gesnel Marie-Claude, Breathnach Richard

Abstract excerpt

TIA-1 and TIAR are a pair of related RNA-binding proteins which have been implicated in apoptosis. We show that chicken DT40 cells with both tia-1 alleles and one tiar allele disrupted (tia-1(-/-)tiar(-/+) cells) are viable. However, their growth and survival in medium containing low serum levels is significantly reduced compared with DT40 cells. The remaining intact tiar allele in tia-1(-/-)tiar(-/+) cells can...

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Identifiers

PMID: 12533540
DOI: 10.1074/jbc.M212378200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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