Article
TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
Molecular cancer research : MCR - 1 Aug 2004
Wang Wei, Nahta Rita, Huper Gudrun, Marks Jeffrey R
Abstract excerpt
TAFII70, a member of the basal transcription complex implicated in p53-mediated transcription, is synthesized as several alternately spliced variants. The predominant forms found in normal and neoplastic breast epithelial cells are shown to be 72 kDa (TAFII70) and 78 kDa (TAFII80). Most cancers express higher levels of the TAFII80 isoform, whereas normal breast epithelia express higher levels of the TAFII70...
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