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Article

Lentivirus-Mediated Silencing of Tiam1 Gene Influences Multiple Functions of a Human Colorectal Cancer Cell Line

1 Nov 2006

Abstract excerpt

T lymphoma invasion and metastasis 1 (Tiam1) is a metastasis-related gene of T lymphoma that is also involved in the metastasis of a variety of other cancers. In this study, we tested the hypothesis that Tiam1 is a determinant of proliferation and metastasis in colorectal cancer, and we examined the effect of the inhibition of Tiam1 expression on proliferation and metastasis. We succeeded in establishing the...

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PMID: 17132223
DOI: 10.1593/neo.06364

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Research trail→

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Lentivirus-Mediated Silencing of Tiam1 Gene Influences Multiple Functions of a Human Colorectal Cancer Cell LinePMID 17132223Read ↗

TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancerSemantic proximity Read ↗

Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells.Semantic proximity Read ↗

MiR-141 Suppresses the Migration and Invasion of HCC Cells by Targeting Tiam1Semantic proximity Read ↗

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model.Semantic proximity Read ↗

Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growthSemantic proximity Read ↗

RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma.Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signalingSemantic proximity Read ↗

MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells.Semantic proximity Read ↗

Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-cell lung cancer cell lineSemantic proximity Read ↗

Talin-1 Correlates with Reduced Invasion and Migration in Human Hepatocellular Carcinoma CellsSemantic proximity Read ↗

Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity.Semantic proximity Read ↗

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