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Article

RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma.

PloS one - 1 Jan 2013

Subramanian Nithya, Navaneethakrishnan Saranya, Biswas Jyotirmay, Kanwar Rupinder K, Kanwar Jagat R, Krishnakumar Subramanian

Abstract excerpt

T lymphoma invasion and metastasis protein (Tiam1) is up-regulated in variety of cancers and its expression level is related to metastatic potential of the type of cancer. Earlier, Tiam1 was shown to be overexpressed in retinoblastoma (RB) and we hypothesized that it was involved in invasiveness of RB. This was tested by silencing Tiam1 in RB cell lines (Y79 and Weri-Rb1) using siRNA pool, targeting different...

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Identifiers

PMID: 23950931
DOI: 10.1371/journal.pone.0070422
PMCID: PMC3737373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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