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The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signaling

2 Dec 2013

Abstract excerpt

The Rho family of GTPases consists of several small proteins that have been described as molecular switches, playing important roles in a wide variety of fundamental cellular processes and in human diseases such as cancer. These proteins, active in the GTP conformation and inactive in the GDP form, are in turn regulated by guanine nucleotide exchange factors (GEFs), guanine nucleotide activating proteins (GAPs)...

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PMID: 24308970
DOI: 10.1016/j.cellsig.2013.11.034

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