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Article

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Cancer cell - 8 May 2017

Diamantopoulou Zoi, White Gavin, Fadlullah Muhammad Z H, Dreger Marcel, Pickering Karen, Maltas Joe, Ashton Garry, MacLeod Ruth, Baillie George S, Kouskoff Valerie, Lacaud Georges, Murray Graeme I, Sansom Owen J, Hurlstone Adam F L, Malliri Angeliki

Abstract excerpt

Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling. We demonstrate that TIAM1 shuttles between the cytoplasm and nucleus antagonizing TAZ/YAP by distinct mechanisms in the two compartments. In the cytoplasm, TIAM1 localizes to the destruction complex and promotes TAZ degradation by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28416184
DOI: 10.1016/j.ccell.2017.03.007
PMCID: PMC5425402

Genes

TIAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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