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Article

TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer

19 Mar 2019

Abstract excerpt

Accumulating evidence suggests that cancer cells with stem cell-like features have higher resistance to chemotherapeutic agents. Herein, we identified T-lymphoma invasion and metastasis-inducing protein-1 (TIAM1) as one of the Wnt-signaling associated genes which drives self-renewal and its expression is upregulated by cancer associated fibroblasts (CAFs). TIAM1 expression was assessed in resected colorectal...

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PMID: 30890693
DOI: 10.1038/s41419-019-1493-5

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