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Article

The LAT story: a tale of cooperativity, coordination, and choreography.

Cold Spring Harbor perspectives in biology - 1 Aug 2010

Balagopalan Lakshmi, Coussens Nathan P, Sherman Eilon, Samelson Lawrence E, Sommers Connie L

Abstract excerpt

The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20610546
DOI: 10.1101/cshperspect.a005512
PMCID: PMC2908767

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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