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Article

LAT polices T cell activation.

Immunity - 21 Aug 2009

Brownlie Rebecca, Zamoyska Rose

Abstract excerpt

Mutations in the adaptor molecule LAT can lead to autoimmunity. In this issue of Immunity, Mingueneau et al. (2009) describe how this may not be a failure of central tolerance.

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Autoimmunity
Share to Lymphocyte Activation
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocyte Subsets

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 19699166
DOI: 10.1016/j.immuni.2009.08.002

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19699166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LAT polices T cell activation.PMID 19699166Read ↗

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.Semantic proximity Read ↗

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.Semantic proximity Read ↗

LAT regulates gammadelta T cell homeostasis and differentiation.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

LAT encodes T cell activation pathway balanceSemantic proximity Read ↗

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events.Semantic proximity Read ↗

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