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Article

A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2011

Fairfax Benjamin P, Davenport Emma E, Makino Seiko, Hill Adrian V S, Vannberg Fredrik O, Knight Julian C

Abstract excerpt

Endotoxin tolerance is characterized by the suppression of further TNF release upon recurrent exposure to LPS. This phenomenon is proposed to act as a homeostatic mechanism preventing uncontrolled cytokine release such as that observed in bacterial sepsis. The regulatory mechanisms and interindividual variation of endotoxin tolerance induction in man remain poorly characterized. In this paper, we describe a...

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Identifiers

PMID: 21282507
DOI: 10.4049/jimmunol.1001791
PMCID: PMC3211060

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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