Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RelB Sustains IκBα Expression during Endotoxin Tolerance

20 Nov 2008

Abstract excerpt

Transcription factors and chromatin structural modifiers induce clinically relevant epigenetic modifications of blood leukocytes during severe systemic inflammation (SSI) in humans and animals. These changes affect genes with distinct functions, as exemplified by the silencing of a set of acute proinflammatory genes and the sustained expression of a group of antimicrobial and anti-inflammatory genes. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19020113
DOI: 10.1128/cvi.00320-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RelB Sustains IκBα Expression during Endotoxin TolerancePMID 19020113Read ↗

Endotoxin Tolerance Disrupts Chromatin Remodeling and NF-κB Transactivation at the IL-1β PromoterSemantic proximity Read ↗

Molecular mechanisms responsible for endotoxin tolerance.Semantic proximity Read ↗

Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene ExpressionSemantic proximity Read ↗

NF-κB1 (p50) Is Upregulated in Lipopolysaccharide Tolerance and Can Block Tumor Necrosis Factor Gene ExpressionSemantic proximity Read ↗

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigensSemantic proximity Read ↗

Endothelial Cells retain inflammatory memory through chromatin remodelingSemantic proximity Read ↗

Transcription of the RelB gene is regulated by NF-kappaB.Semantic proximity Read ↗

NF-κB c-Rel Dictates the Inflammatory Threshold by Acting as a Transcriptional RepressorSemantic proximity Read ↗

A genome-wide analysis of LPS tolerance in macrophages.Semantic proximity Read ↗

Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.Semantic proximity Read ↗

Transcriptional control of the TNF gene.Semantic proximity Read ↗

Generation and Activation of Multiple Dimeric Transcription Factors within the NF-κB Signaling SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.